МІНЕРАЛЬНІ ВОДИ З РІДКІСНОЗЕМЕЛЬНИМИ ЕЛЕМЕНТАМИ ТА ПРОГНОЗУВАННЯ БАЛЬНЕОЛОГІЧНОГО НАПРЯМУ ЇХ ЗАСТОСУВАННЯ
DOI:
https://doi.org/10.30836/igs.2522-9753.2024.321793Ключові слова:
Рідкоземельні елементи, мінеральні води, родовища, бальнеологія, можливості застосуванняАнотація
У статті викладено результати одного з перших досліджень вмісту рідкісноземельних
елементів (РЗЕ) у мінеральних водах Прикарпаття (Львівська область). Виявлено ряд
лантаноїдів у концентраціях, близьких до вмісту РЗЕ в організмі людини, що може
засвідчувати їх потенційну спроможність проявляти бальнеологічний ефект. Аналіз
опублікованих даних показав значний і постійно зростаючий інтерес до розробки ліків
на основі лантаноїдів. Зроблено припущення, що одним із бальнеологічних факторів
виявленого раніше авторами антиканцерогенного ефекту мінеральних вод може бути
наявність в них РЗЕ. За результатами аналізу хімічних властивостей РЗЕ, а також аналізу
літературних даних щодо застосування лантаноїдів у медицині та власних результатів
досліджень пропонується новий напрям дослідження можливого бальнеологічного
застосування мінеральних вод з РЗЕ. Підкреслено, що ця проблема є актуальною,
перш за все, з прикладної точки зору і тому потребує першочергової подальшої науко‑
вої і практичної детальної розробки, а також регіонального дослідження поширення
підземних вод з перспективними концентраціями РЗЕ
Посилання
Balashov Yu. L., 1976. Geochemistry of rare earth elements. M.: Nauka. (In Russian).
Vasilechko V. O., Hryshchuk G. V., Tymoshuk S. V., Shchur R. S., Bilyk O. O., 2006. Chemical-analytical study of waters of Tustan springs. Environment and health. No 1. Pp. 70–74. (In Ukraine).
Galagan M., 1934. Rare earths. A short systematic essay. Prague. (In Ukraine).
Golubeva I. S., Yavorskaya N. P., Baryshnikova M. A., 2010. Use of lanthanoid-based drugs in immunodeficiency. Bioterapeuticheskii journal. No 4. Pp. 89–95. (In Russian).
DSTU ISO 5667-11:2005. Water quality. Sampling of samples. Part 11: Guidelines for the sampling of groundwater (ISO 5667-11:1993, IDT). (In Ukraine).
DSTU ISO 5667-14:2005. Water quality. Sampling of samples. Part 14. Guidelines for quality assurance of sampling and processing of natural water samples (ISO 5667-14:1998, IDT). (In Ukraine).
DSTU 878–93. Mineral drinking water. [Reprint, May 1996]. К. 1996. 88 p. (State Standard of Ukraine). (In Ukraine).
Matolich B. M. (Ed.)., 2007. Economic Atlas of Lviv Oblast. Lviv. (In Ukraine).
Ivanov A. B., Shcherbakov O. D., Usatenko A. V., 2009. Structurally sensitive properties and biomedical applications of lanthanides. Journal Successes of chemistry. Vol. 48, No 9. Pp. 924–941. (In Russian).
Shestopalov V. M. (Ed.)., 2003. Classification of mineral waters of Ukraine. Kyiv: Makkom. (In Russian).
Kostromina N. A., 1990. Chemistry of coordination compounds. M: Publishing house Vyssh. school. (In Russian).
Krainov S. R., 1973. Geochemistry of rare elements in underground waters (in connection with geochemical searches of deposits). M.: Nedra. (In Russian).
Krylov V. V., 2007. Radionuclide therapy of Sm-oxybioforms in metastatic bone lesions. ARF, Obninsk: Med. radiologist center of the Russian Academy of Sciences. (In Russian).
Mikhailov V. A., 2010. Rare earth ores of the world: geology, resources, economy. Kyiv: KSU. (In Russian).
Moiseev A. Yu., 2014. Complexes of trace elements in natural mineral waters. Geochemistry and ore formation. Iss. 34. Pp. 85–93. (In Ukraine).
Moiseev A. Yu., 2017. Peculiarities of the chemical composition and balneological application of mineral waters. Kyiv: Kim. (In Ukraine).
Moiseeva N. P., Shestopalov V. M., Moiseev A. Yu., 2013. Organic matter of mineral waters of the Naftusya type. Geochemistry and ore formation. Iss. 33. Pp. 53–63. (In Russian).
Moiseyev A. Yu., Druzhina M. O., Moiseeva N. P., Shestopalov V. M., 2010. Biological aspects of the use of natural mineral waters. K: Kim. (In Ukraine).
OST 41-08-212-82. "Management of the quality of analytical work. Classification of methods of analysis of mineral raw materials according to the accuracy of the results". (In Russian).
Patent of Ukraine No 2068 dated August 17, 1993. The method of correcting hematopoiesis in case of radiation damage to the body. (In Ukraine).
Pauzina О.А., Apolikhina I.A., Malyshkina D.A., 2020. Possibilities of using neodymium laser (Nd:YAG) in patients with concomitant diseases which are accompanied by pathological discharge from the genital tract. Gynecology. Vol. 22. No 4. Pp. 75–81. DOI:10.26442/20795696.2020.4.200277. (in Russian).
Peshuk L. V., Bavika L. I., Demidov I. M., 2007. Technology of perfume and cosmetic products. K.: Centre for Educational Literature. (In Ukrainian).
Poling L., 1974. General chemistry, Moscow: Mir. (In Russian).
Rukk N. S., Apryshko G. N., Skryabina A. V., 2014. The prospect of creating antitumor drugs based on coordination compounds of elements of the REE group. Russia therapeutic magazine. Vol. 13, No 2. Pp. 14–19. (In Russian).
Certificate of PI-NNF C-77-52865. Medicine, target projects. No 21. 2015. (In Russian).
Trush V. A., 2002. Synthesis, properties and structure of coordination compounds based on dimethyl-N-trichloroacetylamidophosphate. PhD Thesis. KSU named after Taras Shevchenko. Kyiv. (In Ukraine).
Fedyushkin I. L., 2001. Synthesis, structure and properties of complexes of divalent lanthanides with carbo- and heterocyclic aromatic ligands. Dissertation for the scientific degree of doctor of sciences. NGPU named after Minina. (In Russian).
Shestopalov V. M., Moiseeva N. P., Lesyuk. G. V., Kondratyuk E. I., 2022. Mineral waters with rare earth elements. Proceedings of the XX International Scientific and Practical Conference "Natural Water Resources of the Carpathian Region". Lviv. Pp. 133–138. (In Ukraine).
Shestopalov V. M., Moiseyev A. Yu., Druzhina M. O., 2015.Prospects for the use of therapeutic mineral waters in oncology. Bulletin of the National Academy of Sciences of Ukraine. No 9. Pp. 56–63. (In Ukraine).
Shestopalov V. M., Moiseeva N. P., Ischenko A. P., Kondratyuk E. I., Usov V. Yu., Moiseev A. Yu., Gudzenko V. V., Lutyy H. G., Sinitsyn N. I., Suleymanov S. P., Yasevych A. P., Druzhina N. A., Kovalskaya V. V., Gela A. A., Rodionova N. K. Kirilyuk N. D., Rudko G. I., Mytko A. P., Netsky A. V., Bakarzhieva O. O., 2013. Therapeutic mineral waters of the "Naftusia" type of the Ukrainian Carpathians and Podolia. Chernivtsi: Bukrek. (In Russian).
Shestopalov V. M., Moiseeva N. P., Serkiz Ya. I., Pukhova G. G., Gela A. O., Druzhina M. O. USSR Author's Certificate dated 07/24/1989. (In Ukraine).
Yambulatov D. S., 2017. Complexes of 2-valent europium with redox-active ligands. PhD Thesis. IONH RAS. (In Russian).
Yatsimirskyi K. B., Gvyazdovskaya V. L., 1979. Stability constants of metal complexes with bioligands. Kyiv: Naukova dumka. (In Russian).
Ahmad J., Wahab R., Siddiqui M. A., Farshori N. N., Saquib Q., Ahmad N., Al-Khedhairy A. A., 2022. Neodymium oxide nanostructures and their cytotoxic evaluation in human cancer cells. J Trace Elem Med Biol. Vol. 73. 127029. doi: 10.1016/j.jtemb.2022.127029.0.
Aime S., Castelli D. D., Crich S. G., Gianolio E., Terreno E., 2009. Pushing the sensitivity envelope of lanthanide-based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications. Acc Chem Res. Vol. 42. No 7. Pp. 822–831. doi:10.1021/ar800192p.
Antonenco T. A., Shpakovsky D. B., Gracheva Yu. A., Balashova T. V., Pushkarev A. P., Bochkarev M. N., Milaeva E. R., 2012. Lantanoide benzoates with 2,6-di-tert-butilphtnol motets syntehesis luminescent and antioxidant properties. J.Inorganica Chimica Acta. Vol. 455. No 1. Pp. 276–282. https://doi.org/10.1016/j.ica.2016.10.025
Aragón-Muriel A., Liscano-Martínez Y., Rufino-Felipe E., Morales-Morales D., Oñate-Garzón J., Polo-Cerón D., 2020. Synthesis, biological evaluation and model membrane studies on metal complexes containing aromatic N,O-chelate ligands. Heliyon. Vol. 6. No 6 :e04126. doi: https://doi.org/10.1007/s12210-020-00930-w
Azab H.A., Hussein B.H., El-Azab M. F., omaa M., El-Falouji A. I., 2013. Bis(acridine-9-carboxylate)-nitro-europium(III) dihydrate complex a new apoptotic agent through Flk-1 down regulation, caspase-3 activation and oligonucleosomes DNA fragmentation. Bioorg Med Chem. Vol. 21. No 1. Pp. 223–34. doi:10.1016/j.bmc.2012.10.020.
Balaram V., 2019. Rare earth elements: A review of applications, occurrence, exploration, analysis, recycling, and environmental impact. Geoscience Frontiers. Vol. 10. No 4. Pp. 1285–1303. doi:10.1016/j.gsf.2018.12.005
Ban S., Suzuki S., Kubota K., Ohshima S., Satoh H., Imada H., Ueda Y., 2017. Gastric mucosal status susceptible to lanthanum deposition in patients treated with dialysis and lanthanum carbonate. Ann. Diagn. Pathol. Vol. 26. Pp. 6–9. doi:10.1016/j. anndiagpath.2016.10.001
Barker E., Shepherd J., Asencio I. O., 2022. The Use of Cerium Compounds as Antimicrobials for Biomedical Applications. Molecules. Vol. 27. No 9. 2678. doi:10.3390/molecules27092678.
Bellot G. L., Liu D., Fivaz M., Yadav S. K., Kaur C., Pervaiz S., 2024. Lanthanide conjugate Pr-MPO elicits anti-cancer activity by targeting lysosomal machinery and inducing zinc-dependent cataplerosis. Cell Commun Signal. Vol. 22. No 1. 509. doi: 10.1186/s12964-024-01883-5.
Benzli G. C., Pecharsky V., 2017. Handbook on the physics and chemistry of Rare Earts. Vol. 52. I-st Edition including Actinides. Norts-Holland.
Contreras-Martínez G., Gómez-Merino F. C., Peralta-Sánchez M. G., Alcántar-González G., TrejoTéllez L. I., 2022. Biostimulant effects of lanthanum (La) on crop growth, yield, and quality. Agro Productividad. Vol. 15. No 8. Pp. 107–113. https://doi.org/10.32854/agrop.v15i8.2241
da Silva F., Rizk Y. S., das Neves A. R., Lourenço E. M. G., Ferreira A. M. T., Monteiro M. M., de Lima D. P., Perdomo R. T., Bonfá I. S., Toffoli-Kadri M. C., Duarte A. P., Nunes D. M., Martines M. A. U., Piranda E. M., de Arruda C. C. P., 2023. Antileishmanial Activity, Toxicity and Mechanism of Action of Complexes of Sodium Usnate with Lanthanide Ions: Eu(III), Sm(III), Gd(III), Nd(III), La(III) and Tb(III). Int J Mol Sci. Vol.25. No 1. P. 413. doi:10.3390/ijms25010413.
de Oliveira C., Ramos S. J., Siqueira J. O., Faquin V., de Castro E. M., Amaral D. C., Techio V. H., Coelho L. C., e Silva P. H., Schnug E., Guilherme L. R., 2015. Bioaccumulation and effects of lanthanum on growth and mitotic index in soybean plants. Ecotoxicol Environ Saf. Vol. 122. Pp. 136–144. doi:10.1016/j.ecoenv.2015.07.020.
Dong J., Wan T., Li K., Kong X., Shen Q., Wu H., 2022. Mononuclear Dy(III)/heteropolynuclear Zn(II)–Dy(III) Schiff base complexes: Synthesis, structures, fluorescence and antioxidant properties. J. Mol. Struct. Vol. 1264. 133340. https://doi.org/10.1016/j.molstruc.2022.133340
Fang H., Chen C., 2024. Therapeutic effectiveness and safety profile of lanthanum carbonate in conjunction with calcium carbonate for managing hyperphosphatemia in hemodialysis patients: a meta-analysis of randomized controlled trials. Am J Transl Res. Vol. 16. No 11. Pp. 6980–6990. doi:10.62347/WXBL2590.
Fricker S. P., 2006. The therapeutic application of lanthanides. Chem. Soc. Rev. Vol. 35. Pp. 524–33. doi:10.1039/b509608c
Furie B. C., Mann K. G., Furie B., 1976. Substitution of lanthanide ions for calcium ions in the activation of bovine prothrombin by activated factor X. High affinity metal-binding sites of prothrombin and the derivatives of prothrombin activation. J. Biol. Chem. Vol. 251. Pp. 3235–3241. https://doi.org/10.1016/S0021-9258(17)33428-2
Golroudbary S. R., Makarava I., Kraslawski A., Repo E., 2022. Global Environmental Cost of Using Rare Earth Elements in Green Energy Technologies. Sci. Total Environ. Vol. 832. 155022. https://doi.org/10.1016/j.scitotenv.2022.155022
Jorge J., Del Pino Santos K. F., Timóteo F., Vasconcelos R. R. P., Ayala Cáceres O. I., Granja I. J. A., de Souza D. M., Frizon T. E. A., Di Vaccari Botteselle G., Braga A. L., Saba S., Rashid H. U., Rafique J., 2024. Recent Advances on the Antimicrobial Activities of Schiff Bases and their Metal Complexes: An Updated Overview. Curr Med Chem. Vol. 3. No 17. Pp. 2330–2344. doi:10.2174/0929867330666230224092830.
Joy M. S., Kshirsagar A., Candiani C., Brooks T., Hudson J. Q., 2006. Lanthanum carbonate. Ann Pharmacother. Vol. 40. No 2. Pp. 234–40. doi:10.1345/aph.1G224.
Kaczmarek M. T., Zabiszak M., Nowak M., Jastrzab R., 2018. Lanthanides: schiff base complexes, applications in cancer diagnosis, therapy, and antibacterial activity. Coordinat Chem Rev. Vol. 370. Pp. 42–5. doi:10.1016/j.ccr.2018.05.012.
Ketteler M., Wüthrich R. P., Floege J., 2013. Management of hyperphosphataemia in chronic kidney disease-challenges and solutions. Clin Kidney J. Vol. 6. No 2. Pp. 128–36. doi:10.1093/ckj/sfs173.
Li Y., Biswas R., Kopcha W. P., Dubroca T., Abella L., Sun Y., Crichton R. A., Rathnam C., Yang L., Yeh Y. W., Kundu K., Rodríguez-Fortea A., Poblet J. M., Lee K. B., Hill S., Zhang J., 2023. Structurally Defined Water-Soluble Metallofullerene Derivatives towards Biomedical Applications. Angew Chem Int Ed Engl. Vol. 62. No 3. e202211704. doi:10.1002/anie.202211704.
Lloret M. J., Ruiz-García C., Dasilva I., Furlano M., Barreiro Y., Ballarín J., Bover J., 2013. Lanthanum carbonate for the control of hyperphosphatemia in chronic renal failure patients: a new oral powder formulation - safety, efficacy, and patient adherence. Patient Prefer Adherence. Vol. 7. Pp. 1147–56. doi:10.2147/PPA.S31694.
Longo J., Lutz S., Johnstone C., 2013. Samarium-153-ethylene diamine tetramethylene phosphonate, a beta-emitting bone-targeted radiopharmaceutical, useful for patients with osteoblastic bone metastases. Cancer Manag Res. Vol. 5. Pp. 235–242. doi:10.2147/CMAR.S35789.
Martin K. E., Mattocks J. A., Śmiłowicz D., Aluicio-Sarduy E., Whetter J. N., Engle J. W., Cotruvo J. A. Jr, Boros E., 2023. Radiolabeling and in vivo evaluation of lanmodulin with biomedically relevant lanthanide isotopes. RSC Chem Biol. Vol. 4. No 6. Pp. 414–421. doi:10.1039/d3cb00020f.
Nowakowska J., Radomska D., Czarnomysy R., Marciniec K., 2024. Recent Development of Fluoroquinolone Derivatives as Anticancer Agents. Molecules. Vol. 29. No 15. 3538. doi:10.3390/molecules29153538.
Owolabi J., Kizito E., 2024. The Rare Earth Elements: An in-Depth Exploration of Industrial Utilization, Recycling Potential and Environmental Ramifications. Engineering And Technology Journal. Vol. 9. No 01. Pp. 3298–3303. https://doi.org/10.47191/etj/v9i01.07
Porowsky А., Kaczar-Kuzava D., 2016. Pierwiactki ziem zadkich (REE) w wodach terminalnіh – wystepowanie, pochogzenie, znachenie I perspektiwy badan w Polsce. Technica Poschzykivan Geologichnych. R.55. –Nr1. – S. 89-102.
Patyal M., Kaur K., Bala N., Gupta N., Malik A. K., 2023. Innovative lanthanide complexes: Shaping the future of cancer/ tumor chemotherapy. J Trace Elem Med Biol. Vol. 80. Pp. 127277. doi:10.1016/j.jtemb.2023.127277.
Rajeshkumar S., Naik P., 2018. Synthesis and biomedical applications of Cerium oxide nanoparticles—A Review. Biotechnol. Rep. Vol. 17. Pp. 1–5. https://doi.org/10.1016/j.btre.2017.11.008
Rim K.T., 2016. Effects of rare earth elements on the environment and human health: A literature review. Toxicol. Environ. Health Sci. Vol. 8. Pp. 189–200. https://doi.org/10.1007/s13530-016-0276-y
Safinejad M., Rigi A., Zeraati M., Heidary Z., Jahani S., Chauhan N. P. S., Sargazi G., 2022. Lanthanum-based metal organic framework (La-MOF) use of 3,4-dihydroxycinnamic acid as drug delivery system linkers in human breast cancer therapy. BMC Chem. Vol. 16. No 1. 93. doi:10.1186/s13065-022-00886-y.
Sartor O., Reid R. H., Bushnell D. L., Quick D. P., Ell P. J., 2007. Safety and efficacy of repeat administration of samarium Sm-153 lexidronam to patients with metastatic bone pain. Cancer. Vol. 109. No 3. Pp. 637–643. doi:10.1002/cncr.22431.
Schijf J., Byrne R. 2021. Speciation of yttrium and the rare earth elements in seawater: Review of a 20-year analytical journey. Chemical Geology. Vol. 584. 120479. https://doi.org/10.1016/j.chemgeo.2021.120479
Sinicropi M. S., Ceramella J., Iacopetta D., Catalano A., Mariconda A., Rosano C., Saturnino C., El-Kashef H., Longo P., 2022. Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities. Int J Mol Sci. Vol. 23. No 23. 14840. doi:10.3390/ijms232314840.
Su P., Song F., Cao J., Yan C. H., Tang Y., 2025. Rare Earth Complex-Based Functional Materials: From Molecular Design and Performance Regulation to Unique Applications. Acc Chem Res. Vol. 58. No 2. Pp. 218–230. doi:10.1021/acs.accounts.4c00649.
Sung B., Kim H.-K., Baek A.-R., Yang B.-W., Kim Y.-H., Choi G., Park H.-J., Kim M., Lee J., Chang Y., 2023. Nonsteroidal Anti-Inflammatory Drug Conjugated with Gadolinium (III) Complex as an Anti-Inflammatory MRI Agent. International Journal of Molecular Sciences. Vol. 24. No 7. Pp. 6870. https://doi.org/10.3390/ijms24076870
Teo R. D., Termini J., Gray H. B., 2016. Lanthanides: Applications in Cancer Diagnosis and Therapy. J Med Chem. Vol. 59. No 13. 6012–24. doi:10.1021/acs.jmedchem.5b01975.
Tyula Y. A., Goudarziafshar H., Yousefi S., Dušek M., Eigner V., 2023. Template synthesis, characterization and antibacterial activity of d10 (Zn2+, Cd2+, Hg2+) Schiff base complexes: A novel supramolecular Cd2+ complex with two 1D helical chains, and its Hirshfeld surface analysis. J. Mol. Struct. Vol. 1272. Pp. 134051. https://doi.org/10.1016/j.molstruc.2022.134051
Vesković J., Lučić M., Ristić M., Perić-Grujić A., Onjia A., 2024. Spatial Variability of Rare Earth Elements in Groundwater in the Vicinity of a Coal-Fired Power Plant and Associated Health Risk. Toxics. Vol. 12. No 1. 62. https://doi.org/10.3390/toxics12010062
Wang J., Li S., 2022. Applications of rare earth elements in cancer: Evidence mapping and scientometric analysis. Front Med (Lausanne). Vol. 9. 946100. doi:10.3389/fmed.2022.946100.
Wang J., Wang H., Zou F., Gu J., Deng S., Cao Y., Cai K., 2025. The Role of Inorganic Nanomaterials in Overcoming Challenges in Colorectal Cancer Diagnosis and Therapy. Pharmaceutics. Vol. 17. No 4. 409. doi:10.3390/pharmaceutics17040409.
Wysocka I. A., Porowsky, A., Rogowska А. M., Kaczor-Kurzawa D., 2018. Pierwiastki ziem rzadkich (REE) w wodach powierzchniowych i podziemnych Polski na tle innych krajów Europy. Przeglad Geologiczny. Vol. 66. Pp. 692–705. http://dx.doi.org/10.7306/2018.12.
Yaguchi A., Akahane K., Tsuchioka K., Yonekubo S., Yamamoto S., Tamai Y., Tatemichi S., Takeda H., 2019. A comparison between the combined effect of calcium carbonate with sucroferric oxyhydroxide and other phosphate binders: an in vitro and in vivo experimental study. BMC Nephrol. Vol. 20. No 1. 465. doi:10.1186/s12882-019-1655-9.
Yuksel C., Ankarali S., Yuksel N. A., 2018. The use of neodymium magnets in healthcare and their effects on health. North Clin Istanb. Vol. 5. No 3. Pp. 268–273. doi:10.14744/nci.2017.00483.
Zhang C., Wang S., Zhao S., Zhang X., 2017. Effect of lanthanum carbonate on coronary artery calcification and bone mineral density in maintenance hemodialysis patients with diabetes complicated with a dynamic bone disease. Medicine. Vol. 96. Pp. 45–52. doi:10.1097/MD.0000000000008664
1016/j.heliyon.2020.e04126.
Ascenzi P., Bettinelli M., Boffi A., De Simone G., Luchinat C., Marengo E.,Mei H., Aime S. Rare earth elements (REE) in biology and medicine. Rend. Fis. Acc. Lincei. No 1. Pp. 821–833 (2020)